Prof. Dr. Nico Pfeifer

Methods in Medical Informatics
Dr. Nico Pfeifer

Current Position W3 Professor for Computer Science (Methods in Medical Informatics)
Address Department of Computer Science, Sand 14, 72076 Tübingen
Email Surname at


Year Degree College or University (Country) Field of study
2009 Dr. rer. nat. Universität Tübingen (Germany) Bioinformatics/Computational Biology
2005 M.Sc. Universität Göttingen (Germany) Applied Computer Science
2004 B.Sc. Universität Göttingen (Germany) Applied ComputerScience (direction: Bioinformatics)


Period Institution Position Discipline
Since 2017 Universität Tübingen W3 Professor Computer Science
Since 2013 Max Planck Institute for Informatics Group leader Statistical Learning in Computational Biology
2011 – 2012 Max Planck Institute for Informatics Post-Doc Statistical Learning in Computational Biology
2009 – 2011 Microsoft Research Post-Doc Machine Learning in Computational Biology


1.     P. Mendoza, H. Gruell, L. Nogueira, J. Pai, A. Butler, K. Millard, C. Lehmann, I. Suárez, T. Oliveira, J. Lorenzi, Y. Cohen, C. Wyen, T. Kümmerle, T. Karagounis, C.-L. Lu, L. Handl, C. Unson-O’Brien, R. Patel, C. Ruping, M. Schlotz, M. Witmer-Pack, I. Shimeliovich, G. Kremer, E. Thomas, K. Seaton, J. Horowitz, A. West, P. Bjorkman, G. Tomaras, R. Gulick, N. Pfeifer, G. Fätkenheuer, M. Seaman, F. Klein, M. Caskey, M. C. Nussenzweig
Combination therapy with anti-HIV-1 antibodies maintains viral suppression,
Nature 2018, 561, pp 479–4842.

2.     A. Hake and N. Pfeifer
Prediction of HIV-1 sensitivity to broadly neutralizing antibodies shows a trend towards resistance over time,
PLOS Computational Biology 2017, 13(10):e1005789

3.     M. Caskey, T. Schoofs, H. Gruell, A. Settler, T. Karagounis, E. F. Kreider, B. Murrell, N. Pfeifer, L. Nogueira, T. Y. Oliveira, G. H. Learn, Y. Z. Cohen, C. Lehmann, D. Gillor, I. Shimeliovich, C. Unson-O’Brien, D. Weiland, A. Robles, T. Kümmerle, C. Wyen, R. Levin, M. Witmer-Pack, K. Eren, C. Ignacio, S. Kiss, A. P. West, Jr, H. Mouquet, B. S. Zingman, R. M. Gulick, T. Keler, P. J. Bjorkman, M. S. Seaman, B. H. Hahn, G. Fätkenheuer, S. J. Schlesinger, M. C. Nussenzweig, F. Klein
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals,
Nature Medicine 2017, 23, pp 185–1912.2.

4.     M. Döring, P. Borrego, J. Büch, A. Martins, G. Friedrich, R. J. Camacho, J. Eberle, R. Kaiser, T. Lengauer, N. Taveira, N. Pfeifer
A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support
Retrovirology 2016, 13:853.

5.     J. F. Scheid*, J. A. Horwitz*, Y. Bar-On, E. F. Kreider, C.-L. Lu, J. C. C. Lorenzi, A. Feldmann, M. Braunschweig, L. Nogueira, T. Oliveira, I. Shimeliovich, R. Patel, L. Burke, Y. Z. Cohen, S. Hadrigan, A. Settler, M. Witmer-Pack, A. P. West, Jr., B. Juelg, T. Keler, T. Hawthorne, B. Zingman, R. M. Gulick, N. Pfeifer, G. H. Learn, M. S. Seaman, P. J. Bjorkman, F. Klein, S. J. Schlesinger, B. D. Walker, B. H. Hahn, M. C. Nussenzweig, and M. Caskey
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption
Nature 2016, 535, pp 556–560
*: equal contribution

6.     J. M. Carlson†, V. Y. Du*, N. Pfeifer*, A. Bansal, V. Y. F. Tan, K. Power, C. J. Brumme, A. Kreimer, C. E. DeZiel, N. Fusi, M. Schaefer, A. Gladden-Young, M. Brockman, J. Gilmour, M. A. Price, W. Kilembe, R. Haubrich, M. John, S. Mallal, R. Shapiro, J. Frater, P. R. Harrigan, T. Ndung’u, S. Allen, D. Heckerman, J. Sidney, T. M. Allen, P. J. R. Goulder, Z. L. Brumme, E. Hunter†, P. A. Goepfert†,
Impact of Pre-adapted HIV Transmission,
Nature Medicine 2016, 22, pp 606-613
*: equal contribution, †: These authors jointly supervised this work

7.     T. Schoofs*, F. Klein*, M. Braunschweig*, K. F. Kreider, A. Feldmann, L. Nogueira, T. Oliveira, J. C. C. Lorenzi, E. H. Parrish, G. H. Learn, A. P. West, P. J. Bjorkman, S. J. Schlesinger, M. S. Seaman, J. Czartoski, M. J. McElrath, N. Pfeifer, B. H. Hahn, M. Caskey, and M. C. Nussenzweig
HIV-1 Immunotherapy with Monoclonal Antibody 3BNC117 Elicits Host Immune Responses against HIV-1,
Science 2016, 352 (6288), pp 997-1001
*: equal contribution

8.     N. K. Speicher and N. Pfeifer
Integrating Different Data Types by Regularized Unsupervised Multiple Kernel Learning with Application to Cancer Subtype Discovery,
Proceedings of ISMB/ECCB 2015, Bioinformatics 2015, 31, pp i268-i275

9.     N. Pfeifer, H. Walter, T. Lengauer
Association between HIV-1 coreceptor usage and resistance to broadly neutralizing antibodies,
JAIDS 2014, 67 (2), pp 107-112

10.  N. Pfeifer and T. Lengauer
Improving HIV coreceptor usage prediction in the clinic using hints from next generation sequencing data
“Proceedings of the 11th European Conference on Computational Biology (ECCB 2012)”, Bioinformatics 2012 28, i589-i595.

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